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Expression of GTP-binding protein alpha subunits in human thymocytes

Kabouridis, PS; Waters, ST; Escobar, S; Stanners, J; Tsoukas, CD; (1995) Expression of GTP-binding protein alpha subunits in human thymocytes. Molecular and Cellular Biochemistry , 144 (1) 45 - 51. 10.1007/BF00926739.

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Abstract

In this report, we investigate G protein α subunit diversity in human thymocytes, utilizing common properties shared by these genes and reverse transcription-polymerase chain reaction (RT-PCR). Sequence analysis of PCR amplified gene portions, indicate the presence of members from all four G-protein families that have been described thus far. The α subunit genes identified are: Gα and Gα but not Gα from the G family, Gα from the G family, Gα, Gα, and Gα from the G family, and Gα and Gα from the G family. Also in this report we present the nucleotide and predicted amino acid sequences of the human Gα cloned from a thymocyte cDNA library. The sequence of the human Gα has not been previously reported. Comparison of this sequence with the reported murine Gα shows >90% identity at the deduced amino acid sequence level. We conclude that thymocytes represent a useful experimental system fo the study of G protein involvement in immune responses and lymphocyte development. © 1995 Kluwer Academic Publishers.

Type:Article
Title:Expression of GTP-binding protein alpha subunits in human thymocytes
DOI:10.1007/BF00926739
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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