UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Lipid rafts in T cell receptor signalling .

Kabouridis, PS; (2006) Lipid rafts in T cell receptor signalling . Mol Membr Biol , 23 (1) pp. 49-57. 10.1080/09687860500453673.

Full text not available from this repository.


The molecular events and the protein components that are involved in signalling by the T cell receptor (TCR) for antigen have been extensively studied. Activation of signalling cascades following TCR stimulation depends on the phosphorylation of the receptor by the tyrosine kinase Lck, which localizes to the cytoplasmic face of the plasma membrane by virtue of its post-translational modification. However, the precise order of events during TCR phosphorylation at the plasma membrane, remains to be defined. A current theory that describes early signalling events incorporates the function of lipid rafts, microdomains at the plasma membrane with distinct lipid and protein composition. Lipid rafts have been implicated in diverse biological functions in mammalian cells. In T cells, molecules with a key role in TCR signalling, including Lck, localize to these domains. Importantly, mutant versions of these proteins which fail to localise to raft domains were unable to support signalling by the TCR. Biochemical studies using purified detergent-resistant membranes (DRM) and confocal microscopy have suggested that upon stimulation, the TCR and Lck-containing lipid rafts may come into proximity allowing phosphorylation of the receptor. Further, there are data suggesting that phosphorylation of the TCR could depend on a transient increase in Lck activity that takes place within lipid rafts to initiate signalling. Current results and a model of how lipid rafts may regulate TCR signalling are discussed.

Type: Article
Title: Lipid rafts in T cell receptor signalling .
Location: England
DOI: 10.1080/09687860500453673
Keywords: Adaptor Proteins, Signal Transducing, Animals, Humans, In Vitro Techniques, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Membrane Microdomains, Models, Immunological, Phosphorylation, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes
URI: http://discovery.ucl.ac.uk/id/eprint/1319187
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item