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X-Chromosome Lineages and the Settlement of the Americas

Bourgeois, S; Yotova, V; Wang, SJ; Bourtoumieu, S; Moreau, C; Michalski, R; Moisan, JP; ... Labuda, D; + view all (2009) X-Chromosome Lineages and the Settlement of the Americas. AM J PHYS ANTHROPOL , 140 (3) 417 - 428. 10.1002/ajpa.21084.

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Abstract

Most genetic Studies oil the origins of Native Americans have examined data from mtDNA and Y-chromosome DNA. To complement these studies and to broaden our understanding of the origin of Native American populations, we present an analysis of 1,873 X-chromosomes representing Native American (n = 438) and other continental populations (n = 1,435). We genotyped 36 polymorphic sites, forming an informative haplotype within an 8-kb DNA segment spanning exon 44 of the dystrophin gene. The data reveal continuity from a common Eurasian ancestry between European, Siberians, and Native Americans However, the loss of two haplotypes frequent in Eurasia (18.8 and 7%) and the rise in frequency of a third haplotype rare elsewhere, indicate a major population bottleneck in the peopling of the Americas. Although genetic drift appears to have played a greater role in the genetic differentiation of Native Americans than in the latitudinally distributed Eurasians, we also observe a signal of a differentiated ancestry of southern and northern populations that cannot be simply explained by the serial southward dilution of genetic diversity It is possible that the distribution of X-chromosome lineages reflects the genetic structure of the population of Beringia, itself issued from founder effects and a source of subsequent southern colonization(s). Am J Phys Anthropol 140.417-428, 2009. (C) 2009 Wiley-Liss, Inc

Type: Article
Title: X-Chromosome Lineages and the Settlement of the Americas
DOI: 10.1002/ajpa.21084
Keywords: Amerindians, population genetics, genetic structure, migration, MITOCHONDRIAL-DNA ANALYSIS, NATIVE NORTH AMERICANS, NEW-WORLD, MODERN HUMANS, Y-CHROMOSOMES, POPULATION-STRUCTURE, MTDNA HAPLOGROUPS, GENE FLOW, HAPLOTYPES, DIVERSITY
UCL classification: UCL > Office of the President and Provost
UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1319156
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