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Intersession repeatability of a novel nasal lavage technique

Alahmari, MD; Sapsford, RJ; Wedzicha, JA; Hurst, JR; (2011) Intersession repeatability of a novel nasal lavage technique. TRANSL RES , 158 (3) 163 - 168. 10.1016/j.trsl.2011.04.001.

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Abstract

This study describes a novel nasal lavage method using a pediatric tracheostomy tube and examines intersession repeatability for several clinically and technically relevant parameters. Fourteen healthy subjects were included in this study. Both nasal cavities were washed using a standard amount of saline solution (7 mL) via a pediatric tracheostomy tube, and the 2 samples were pooled for measurement of cytokine concentrations and cell count. Recovery volume was also recorded. For each subject, measurements were repeated on 5 consecutive days. Intersession repeatability of recovery volume, cell count, and cytokine concentrations interleukin (IL)-6 and IL-8 were expressed in terms of mean coefficient of variation, intraclass correlation coefficient, and interitem correlations. Intraclass correlation coefficients and interitem correlation coefficients indicated almost perfect agreement for cell count and IL-8 concentrations. Recovery volume and IL-6 concentrations were more variable. The mean coefficient of variation was low for cell count (2%), IL-8 concentration (3%), and recovery volume (3%), whereas the mean percentage recovery was high (87%). This newly developed nasal lavage technique is repeatable over successive sessions for cytokine concentrations and cell counts in nasal secretions of healthy subjects. This method might be valuable in the study of inflammatory conditions involving the upper respiratory tract. (Translational Research 2011;158:163-168)

Type: Article
Title: Intersession repeatability of a novel nasal lavage technique
DOI: 10.1016/j.trsl.2011.04.001
Keywords: UPPER-AIRWAY, ULTRASONIC NEBULIZATION, BIOCHEMICAL-ANALYSIS, HYPERTONIC SOLUTION, COLLECTION METHOD, CATIONIC PROTEIN, SECRETIONS, MARKERS, INFLAMMATION, DILUTION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/1318798
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