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Dissociable reward and timing signals in human midbrain and ventral striatum.

Klein-Flügge, MC; Hunt, LT; Bach, DR; Dolan, RJ; Behrens, TE; (2011) Dissociable reward and timing signals in human midbrain and ventral striatum. Neuron , 72 (4) 654 - 664. 10.1016/j.neuron.2011.08.024. Gold open access

Abstract

Reward prediction error (RPE) signals are central to current models of reward-learning. Temporal difference (TD) learning models posit that these signals should be modulated by predictions, not only of magnitude but also timing of reward. Here we show that BOLD activity in the VTA conforms to such TD predictions: responses to unexpected rewards are modulated by a temporal hazard function and activity between a predictive stimulus and reward is depressed in proportion to predicted reward. By contrast, BOLD activity in ventral striatum (VS) does not reflect a TD RPE, but instead encodes a signal on the variable relevant for behavior, here timing but not magnitude of reward. The results have important implications for dopaminergic models of cortico-striatal learning and suggest a modification of the conventional view that VS BOLD necessarily reflects inputs from dopaminergic VTA neurons signaling an RPE.

Type: Article
Title: Dissociable reward and timing signals in human midbrain and ventral striatum.
Location: United States
Open access status: An open access publication
DOI: 10.1016/j.neuron.2011.08.024
Language: English
Additional information: PMCID: PMC3219831
Keywords: Adult, Basal Ganglia, Female, Humans, Magnetic Resonance Imaging, Male, Mesencephalon, Photic Stimulation, Psychomotor Performance, Reward, Time Factors, Young Adult
URI: http://discovery.ucl.ac.uk/id/eprint/1318757
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