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Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk

Calabresi, L; Baldassarre, D; Simonelli, S; Gomaraschi, M; Amato, M; Castelnuovo, S; ... Tremoli, E; + view all (2011) Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk. J LIPID RES , 52 (8) 1569 - 1574. 10.1194/jlr.P014977. Gold open access

Abstract

Lecithin: cholesterol acyltransferase (LCAT) is the enzyme responsible for cholesterol esterification in plasma. LCAT is a major factor in HDL remodeling and metabolism, and it has long been believed to play a critical role in macrophage reverse cholesterol transport (RCT). The effect of LCAT on human atherogenesis is still controversial. In the present study, the plasma LCAT concentration was measured in all subjects (n = 540) not on drug treatment at the time of enrollment in the multicenter, longitudinal, observational IMPROVE study. Mean and maximum intima-media thickness (IMT) of the whole carotid tree was measured by B-mode ultrasonography in all subjects. In the entire cohort, LCAT quartiles were not associated with carotid mean and maximum IMT (P for trend 0.95 and 0.18, respectively), also after adjustment for age, gender, HDL-cholesterol (HDL-C), and triglycerides. No association between carotid IMT and LCAT quartiles was observed in men (P=0.30 and P=0.99 for mean and maximum IMT, respectively), whereas carotid IMT increased with LCAT quartiles in women (P for trend 0.14 and 0.019 for mean and maximum IMT, respectively). The present findings support the concept that LCAT is not required for an efficient reverse cholesterol transport and that a low plasma LCAT concentration and activity is not associated with increased atherosclerosis.-Calabresi, L., D. Baldassarre, S. Simonelli, M. Gomaraschi, M. Amato, S. Castelnuovo, B. Frigerio, A. Ravani, D. Sansaro, J. Kauhanen, R. Rauramaa, U. de Faire, A. Hamsten, A. J. Smit, E. Mannarino, S. E. Humphries, P. Giral, F. Veglia, C. R. Sirtori, G. Franceschini, and E. Tremoli. Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk. J. Lipid Res. 2011. 52: 1569-1574.

Type:Article
Title:Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk
Open access status:An open access publication
DOI:10.1194/jlr.P014977
Keywords:atherosclerosis, cardiovascular disease, high density lipoproteins, HIGH-DENSITY-LIPOPROTEIN, ARTERY INTIMA, CORONARY ATHEROSCLEROSIS, MYOCARDIAL-INFARCTION, MAJOR DETERMINANTS, IN-VIVO, DISEASE, ANGIOGRAPHY, ULTRASOUND, IDENTIFY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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