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Review article: pancreatic renin-angiotensin systems in health and disease

Skipworth, JRA; Szabadkai, G; Damink, SWMO; Leung, PS; Humphries, SE; Montgomery, HE; (2011) Review article: pancreatic renin-angiotensin systems in health and disease. ALIMENT PHARM THER , 34 (8) 840 - 852. 10.1111/j.1365-2036.2011.04810.x.

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Abstract

BackgroundIn addition to the circulating (endocrine) renin-angiotensin system (RAS), local renin-angiotensin systems are now known to exist in diverse cells and tissues. Amongst these, pancreatic renin-angiotensin systems have recently been identified and may play roles in the physiological regulation of pancreatic function, as well as being implicated in the pathogenesis of pancreatic diseases including diabetes, pancreatitis and pancreatic cancer.AimTo review and summarise current knowledge of pancreatic renin-angiotensin systems.MethodsWe performed an extensive PubMed, Medline and online review of all relevant literature.ResultsPancreatic RAS appear to play various roles in the regulation of pancreatic physiology and pathophysiology. Ang II may play a role in the development of pancreatic ductal adenocarcinoma, via stimulation of angiogenesis and prevention of chemotherapy toxicity, as well as in the initiation and propagation of acute pancreatitis (AP); whereas, RAS antagonism is capable of preventing new-onset diabetes and improving glycaemic control in diabetic patients. Current evidence for the roles of pancreatic RAS is largely based upon cell and animal models, whilst definitive evidence from human studies remains lacking.ConclusionsThe therapeutic potential for RAS antagonism, using cheap and widely available agents, and may be untapped and such roles are worthy of active investigation in diverse pancreatic disease states. Aliment Pharmacol Ther 2011; 34: 840-852

Type:Article
Title:Review article: pancreatic renin-angiotensin systems in health and disease
DOI:10.1111/j.1365-2036.2011.04810.x
Keywords:II TYPE-1 RECEPTOR, CONVERTING-ENZYME-INHIBITORS, ISLET BLOOD-FLOW, FACTOR-KAPPA-B, EXTRACELLULAR-MATRIX PRODUCTION, RANDOMIZED CLINICAL-TRIALS, BETA-CELL FUNCTION, PROTEIN-KINASE-C, DIABETES-MELLITUS, INSULIN-SECRETION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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