Knowles, R.L. (2011) Modelling childhood survival with serious congenital heart defects. Doctoral thesis, UCL (University College London).
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Congenital heart defects (CHDs) are the most prevalent type of congenital anomaly and the principal cause of death from congenital anomalies during infancy. However reliable information about longer-term survival and the factors predictive of death during later childhood is lacking. In this thesis, I report the findings of a multicentre cohort study established to estimate survival with serious CHDs from birth to 15 years of age and to investigate the independent effects of early life and procedure-related factors on mortality risk. The hospital records of 3,897 children (57% boys) born in the UK between 1992 and 1995 and who required intervention or died in the first year of life were reviewed. Multiple imputation of missing data including time varying covariates was performed using multilevel statistical techniques. Survival was estimated using Kaplan-Meier, Cox proportional hazards and multilevel models and predictive factors evaluated using step-wise logistic regression models using complete case as well as multiple imputed datasets. By 15 years of age, 932 children had died, 144 without any procedure. Overall, survival to one year was 79.8% (95% Confidence Intervals [CI] 78.5, 81.1%) and to 15 years was 71.7% (63.9, 73.4%), with variation by cardiac diagnosis. In the multilevel imputed data model including children who had at least one procedure, higher mortality risk was independently associated with multiple cardiac malformations, younger age at first procedure, lower weight and/or height, longer duration of cardiopulmonary bypass and circulatory arrest, and presence of pre- or post-procedure complications. Although the risk of death from CHDs is highest in the first year, an important continuing risk of death remains throughout childhood. Early life and procedure-related factors predict mortality risk independently of CHD diagnosis. Future research should address social, educational, and health outcomes in later childhood to understand the impact of advances in diagnosis and management of CHDs.
|Title:||Modelling childhood survival with serious congenital heart defects|
|Additional information:||Permission for digitisation not received|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Population Health Sciences > ICH - Paediatric Epidemiology Unit|
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