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Development of acute opioid tolerance and dependence in rat striatal neurones

Fry, JP; Zieglgänsberger, W; Herz, A; (1980) Development of acute opioid tolerance and dependence in rat striatal neurones. Naunyn-Schmiedeberg's Archives of Pharmacology , 313 (2) 145 - 149. 10.1007/BF00498571.

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Abstract

Striatal neurones in the rat were frequently observed to develop tachyphylaxis to the specific, naloxone-antagonisable depressant effects of methionine-and leucine-enkephalin on spontaneous and L-glutamate-evoked activity. This loss of responsiveness to the enkephalins occurred within a few minutes of the repeated or prolonged application of these peptides and is suggested to reflect a form of acute tolerance. As with chronic opiate tolerance, the acute tolerance of single striatal neurones to the enkephalins appeared to be associated with dependence on these opioids, as evinced by the withdrawal-like hyperactivity that occurred upon terminating the application of the peptides or upon the microelectrophoresis of naloxone.

Type: Article
Title: Development of acute opioid tolerance and dependence in rat striatal neurones
DOI: 10.1007/BF00498571
Publisher version: http://dx.doi.org/10.1007/BF00498571
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/BF00498571.
Keywords: Enkephalin, Acute tolerance, Opioid dependence, Naloxone Striatum
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/1317410
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