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REGULATION OF GENE-EXPRESSION IN ASTROCYTES BY EXCITATORY AMINO-ACIDS

MCNAUGHTON, LA; HUNT, SP; (1992) REGULATION OF GENE-EXPRESSION IN ASTROCYTES BY EXCITATORY AMINO-ACIDS. MOL BRAIN RES , 16 (3-4) 261 - 266.

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Abstract

We have studied the effect of excitatory amino acids on the expression of mRNA for the immediate early genes c-fos, c-jun, jun-B, and NGF-1A in isolated cortical astrocytes. The expression of the different genes was induced by 100 muM kainate, quisqualate, AMPA and high concentrations of K+ (140 mM). NMDA did not induce the expression of any of the genes studied. The effect of quisqualate stimulation was not inhibited by the antagonist CNQX or by withdrawal of external Ca2+. In contrast the kainate effect was abolished by CNQX but not by the removal of external Ca2+. However, elevated K+ induced c-fos only when calcium was present in the external medium. These findings suggest that type-1 astrocytes lack NMDA receptors and that the induction of genes by quisqualate and kainate is in part independent of the presence of calcium in the external medium and may be mediated through second messenger pathways.

Type: Article
Title: REGULATION OF GENE-EXPRESSION IN ASTROCYTES BY EXCITATORY AMINO-ACIDS
Keywords: ASTROCYTE, QUISQUALATE, KAINATE, HIGH[K+], GENE EXPRESSION, IMMEDIATE EARLY GENE, C-FOS EXPRESSION, GROWTH-FACTORS, RECEPTORS, BRAIN, INDUCTION, CHANNELS, PROTEIN, BINDING, JUN, STIMULATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1316104
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