UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

A longer and healthier life with TOR down-regulation: genetics and drugs

Bjedov, I; Partridge, L; (2011) A longer and healthier life with TOR down-regulation: genetics and drugs. In: BIOCHEMICAL SOCIETY TRANSACTIONS. (pp. 460 - 465). PORTLAND PRESS LTD

Full text not available from this repository.

Abstract

Genetic down-regulation of a major nutrient-sensing pathway, TOR (target of rapamycin) signalling, can improve health and extend lifespan in evolutionarily distant organisms such as yeast and mammals. Recently, it has been demonstrated that treatment with a pharmacological inhibitor of the TOR pathway, rapamycin, can replicate those findings and improve aging in a variety of model organisms. The proposed underlying anti-aging mechanisms are down-regulated translation, increased autophagy, altered metabolism and increased stress resistance.

Type: Proceedings paper
Title: A longer and healthier life with TOR down-regulation: genetics and drugs
Event: Focused Meeting of the Biochemical-Society on mTOR Signalling in Health and Disease
Location: London, ENGLAND
Dates: 2010-11-11 - 2010-11-12
DOI: 10.1042/BST0390460
Keywords: aging, autophagy, metabolism, stress, target of rapamycin (TOR), translation, DIET-INDUCED OBESITY, MTOR COMPLEX 1, SPAN EXTENSION, TRANSLATIONAL CONTROL, SIGNALING PATHWAY, GROWTH-FACTORS, C-ELEGANS, MECHANISMS, DROSOPHILA, AUTOPHAGY
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Genetics, Evolution and Environment
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology
URI: http://discovery.ucl.ac.uk/id/eprint/1315726
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item