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Optical properties of tissue measured using terahertz pulsed imaging

Berry, E; Fitzgerald, AJ; Zinov'ev, NN; Walker, GC; Homer-Vanniasinkam, S; Sudworth, CD; Miles, RE; ... Smith, MA; + view all (2003) Optical properties of tissue measured using terahertz pulsed imaging. In: Yaffe, MK and Antonuk, LE, (eds.) MEDICAL IMAGING 2003: PHYSICS OF MEDICAL IMAGING, PTS 1 AND 2. (pp. 459 - 470). SPIE-INT SOC OPTICAL ENGINEERING

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Abstract

The first demonstrations of terahertz imaging in biomedicine were made several years ago, but few data are available on the optical properties of human tissue at terahertz frequencies. A catalogue of these properties has been established to estimate variability and determine the practicality of proposed medical applications in terms of penetration depth, image contrast and reflection at boundaries. A pulsed terahertz imaging system with a useful bandwidth 0.5-2.5 THz was used. Local ethical committee approval was obtained. Transmission measurements were made through tissue slices of thickness 0.08 to 1 mm, including tooth enamel and dentine, cortical bone, skin, adipose tissue and striated muscle. The mean and standard deviation for refractive index and linear attenuation coefficient, both broadband and as a function of frequency, were calculated. The measurements were used in simple models of the transmission, reflection and propagation of terahertz radiation in potential medical applications. Refractive indices ranged from 1.5 +/- 0.5 for adipose tissue to 3.06 +/- 0.09 for tooth enamel. Significant differences (P < 0.05) were found between the broadband refractive indices of a number of tissues. Terahertz radiation is strongly absorbed in tissue so reflection imaging, which has lower penetration requirements than transmission, shows promise for dental or dermatological applications.

Type: Proceedings paper
Title: Optical properties of tissue measured using terahertz pulsed imaging
Event: Medical Imaging 2003 Conference
Location: SAN DIEGO, CA
Dates: 2003-02-17 - 2003-02-20
ISBN: 0-8194-4831-1
Keywords: refractive index, linear absorption coefficient, human tissue, terahertz pulsed imaging, medical applications, DIELECTRIC-PROPERTIES, SKIN TISSUE, HISTOPATHOLOGICAL SAMPLES, REFLECTION GEOMETRY, BIOLOGICAL TISSUES, DENTAL DIAGNOSIS, MILLIMETER WAVES, SPECTROSCOPY, SYSTEM, GHZ
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/1315294
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