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THE PREVALENCE OF INFLAMMATORY BOWEL-DISEASE IN RELATIVES OF PATIENTS WITH CROHNS-DISEASE

SATSANGI, J; ROSENBERG, WMC; JEWELL, DP; (1994) THE PREVALENCE OF INFLAMMATORY BOWEL-DISEASE IN RELATIVES OF PATIENTS WITH CROHNS-DISEASE. EUR J GASTROEN HEPAT , 6 (5) 413 - 416.

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Abstract

Objective: To determine the prevalence of inflammatory bowel disease (IBD) in relatives of patients with Crohn's disease.Methods: Postal questionnaire supplemented by review of case notes (for all patients). Interviews (personal or telephone) were carried out to confirm a positive family history.Patients: Complete information was obtained from 433 adult patients with Crohn's disease. Ages ranged from 17-85 years. More than 95% of patients were resident locally.Results: In 78 families (18%), at least one first- or second-degree relative also had IBD; three relatives were affected in 14 families and four in two families. Both Crohn's disease and ulcerative colitis occurred in these multiply-affected pedigrees. First-degree relatives were affected in 50 families (11.5%). Siblings were most affected (33 siblings in 29 families). Crohn's disease (20 siblings) was more common than ulcerative colitis (13 siblings); 19 parents and four offspring were affected. A spouse was affected in one family only. IBD was not present in families of adopted Crohn's disease patients. Assuming a population prevalence of 170/100 000 for IBD, the relative risks for IBD in siblings, parents and offspring of patients with Crohn's disease calculated from these data are, respectively, 24.7, 12.5 and 4.41.Conclusion: These data confirm the increased prevalence of IBD in families of patients with Crohn's disease. Genetic susceptibility appears to be implicated in disease pathogenesis.

Type:Article
Title:THE PREVALENCE OF INFLAMMATORY BOWEL-DISEASE IN RELATIVES OF PATIENTS WITH CROHNS-DISEASE
Keywords:FAMILIAL INFLAMMATORY BOWEL DISEASE

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