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HLA-DR AND HLA-DP GENOTYPES AND IMMUNOGLOBULIN-E RESPONSES TO COMMON MAJOR ALLERGENS

YOUNG, RP; DEKKER, JW; WORDSWORTH, BP; SCHOU, C; PILE, KD; MATTHIESEN, F; ... COOKSON, WOCM; + view all (1994) HLA-DR AND HLA-DP GENOTYPES AND IMMUNOGLOBULIN-E RESPONSES TO COMMON MAJOR ALLERGENS. CLIN EXP ALLERGY , 24 (5) 431 - 439.

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Abstract

In order to test for human histocompatibility leucocyte antigens (HLA) class II restriction of IgE responses, 431 subjects from 83 families were genotyped at the HLA-DR and HLA-DP loci and serotyped for IgE responses to six major allergens from common aero-allergen sources. A possible excess of HLA-DR1 was found in subjects who were responsive to Fel dI compared with those who were not (Odds Ratio (OR) = 2, P = 0.002), and a possible excess of HLA-DR4 was found in subjects responsive to Alt a I (OR = 1.9, P = 0.006). Increased sharing of HLA-DR/DP haplotypes was seen in sibling pairs responding to both allergens. Der p I, Del p II, Phl p V and Can f I were not associated with any definite excess of HLA-DR alleles. No significant correlations were seen with HLA-DP genotype and reactivity to any of the allergens. The results suggest class II HLA restriction is insufficient to account for individual differences in reactivity to common allergens.

Type:Article
Title:HLA-DR AND HLA-DP GENOTYPES AND IMMUNOGLOBULIN-E RESPONSES TO COMMON MAJOR ALLERGENS
Keywords:HOUSE-DUST MITE, BRONCHIAL HYPERRESPONSIVENESS, IMMUNE RESPONSIVENESS, RELATIVE RISKS, P-I, POLLEN, ASTHMA, PURIFICATION, ASSOCIATION, CHILDHOOD

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