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ISOLATED HLA-DP MISMATCHES BETWEEN DONORS AND RECIPIENTS DO NOT INFLUENCE THE FUNCTION OR OUTCOME OF RENAL-TRANSPLANTS

ROSENBERG, WMC; BUSHELL, A; HIGGINS, RM; WORDSWORTH, BP; WOOD, KJ; BELL, JI; MORRIS, PJ; (1992) ISOLATED HLA-DP MISMATCHES BETWEEN DONORS AND RECIPIENTS DO NOT INFLUENCE THE FUNCTION OR OUTCOME OF RENAL-TRANSPLANTS. HUM IMMUNOL , 33 (1) 5 - 9.

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Abstract

The matching of donors and renal graft recipients for human leukocyte antigens A, B, and DR has been shown to exert beneficial effects on the out-come of transplanation. Until the advent of polymerase chain reaction amplification-based genotyping, the effect of HLA-DP compatibility on graft survival could not be thoroughly investigated. HLA-DP compatibility has been determined in three living-related transplants and 34 cadaveric transplants for donor-recipient pairs matched for HLA-DR and -DQ. The effect of DP mismatching on graft surival and function was assessed. No clear benefit from matching donor and recipient for HLA-DP could be discerned.

Type:Article
Title:ISOLATED HLA-DP MISMATCHES BETWEEN DONORS AND RECIPIENTS DO NOT INFLUENCE THE FUNCTION OR OUTCOME OF RENAL-TRANSPLANTS
Keywords:ALLOGRAFTS, ANTIGENS

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