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EXTENSIVE CONSERVATION OF ALPHA-CHAIN AND BETA-CHAIN OF THE HUMAN T-CELL ANTIGEN RECEPTOR RECOGNIZING HLA-A2 AND INFLUENZA-A MATRIX PEPTIDE

MOSS, PAH; MOOTS, RJ; ROSENBERG, WMC; ROWLANDJONES, SJ; BODMER, HC; MCMICHAEL, AJ; BELL, JI; (1991) EXTENSIVE CONSERVATION OF ALPHA-CHAIN AND BETA-CHAIN OF THE HUMAN T-CELL ANTIGEN RECEPTOR RECOGNIZING HLA-A2 AND INFLUENZA-A MATRIX PEPTIDE. P NATL ACAD SCI USA , 88 (20) 8987 - 8990.

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Abstract

The major histocompatibility complex class I molecule HLA-A2.1 presents the influenza A virus matrix peptide 57-68 to cytotoxic T lymphocytes in all individuals with this common HLA type and is among the most thoroughly studied immune responses in humans. We have studied the T-cell receptor (TCR) heterogeneity of T cells specific for HLA-A2 and influenza A matrix peptide using the polymerase chain reaction. The usage of V-alpha and V-beta-sequences seen on these T cells is remarkably conserved as are certain junctional sequences associated with alpha and beta-chains. Furthermore, two unrelated HLA-A2 individuals have a similar pattern of TCR usage, implying that this is a predominant response in HLA-A2 populations. Analysis in one individual showed that the conserved TCR V-alpha and V-beta-genes are minor members of the peripheral blood TCR repertoire. The sequences provide important information on the TCR necessary for the final structural analysis of this ternary complex.

Type:Article
Title:EXTENSIVE CONSERVATION OF ALPHA-CHAIN AND BETA-CHAIN OF THE HUMAN T-CELL ANTIGEN RECEPTOR RECOGNIZING HLA-A2 AND INFLUENZA-A MATRIX PEPTIDE
Keywords:TOXIC LYMPHOCYTES-T, VARIABLE REGION GENES, JUNCTIONAL REGIONS, VIRAL PEPTIDE, BINDING-SITE, RECOGNITION, PROTEIN, SPECIFICITY, REPERTOIRE, SEQUENCES

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