Hoogewijs, D and Terwilliger, NB and Webster, KA and Powell-Coffman, JA and Tokishita, S and Yamagata, H and Hankeln, T and Burmester, T and Rytkönen, KT and Nikinmaa, M and Abele, D and Heise, K and Lucassen, M and Fandrey, J and Maxwell, PH and Påhlman, S and Gorr, TA (2007) From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia. Integr Comp Biol , 47 (4) 552 - 577. 10.1093/icb/icm072.
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Abstract
The objective of this symposium at the First International Congress of Respiratory Biology (ICRB) was to enhance communication between comparative biologists and cancer researchers working on O(2) sensing via the HIF pathway. Representatives from both camps came together on August 13-16, 2006, in Bonn, Germany, to discuss molecular adaptations that occur after cells have been challenged by a reduced (hypoxia) or completely absent (anoxia) supply of oxygen. This brief "critters-to-cancer" survey discusses current projects and new directions aimed at improving understanding of hypoxic signaling and developing therapeutic interventions.
| Type: | Article |
|---|---|
| Title: | From critters to cancers: bridging comparative and clinical research on oxygen sensing, HIF signaling, and adaptations towards hypoxia. |
| DOI: | 10.1093/icb/icm072 |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) |
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