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Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies.

Nherera, L; Marks, D; Minhas, R; Thorogood, M; Humphries, SE; (2011) Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies. Heart , 97 (14) pp. 1175-1181. 10.1136/hrt.2010.213975.

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Abstract

To estimate the probabilistic cost-effectiveness of cascade screening methods in familial hypercholesterolaemia (FH) from the UK NHS perspective.

Type: Article
Title: Probabilistic cost-effectiveness analysis of cascade screening for familial hypercholesterolaemia using alternative diagnostic and identification strategies.
Location: England
DOI: 10.1136/hrt.2010.213975
Keywords: Adult, Biological Markers, Cardiovascular Diseases, Cholesterol, LDL, Cost-Benefit Analysis, Drug Costs, False Negative Reactions, False Positive Reactions, Genetic Predisposition to Disease, Genetic Testing, Great Britain, Health Care Costs, Heredity, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hyperlipoproteinemia Type II, Markov Chains, Mass Screening, Middle Aged, Models, Economic, Mutation, Pedigree, Predictive Value of Tests, Probability, Prognosis, Quality-Adjusted Life Years, State Medicine, Time Factors
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1315065
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