Caygill, CPJ and Royston, C and Charlett, A and Wall, CM and Gatenby, PAC and Ramus, JR and Watson, A and Winslet, M and Hourigan, CS and Bardhan, KD (2011) Barrett's, blood groups and progression to oesophageal cancer: is nitric oxide the link? EUR J GASTROEN HEPAT , 23 (9) 801 - 806. 10.1097/MEG.0b013e3283489dcf.
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Introduction Incidence of oesophageal adenocarcinoma (OAC) is increasing rapidly. OAC arises in columnar-lined oesophagus (CLO), a metaplastic change affecting some patients with gastro-oesophageal reflux disease (GORD). As yet there is no reliable method of identifying those at highest risk. Our earlier observation of an association between OAC and blood group O Rhesus negative, if confirmed, may help identify those at greatest risk.Aim and methods To assess the distribution of blood group and Rhesus D (RhD) factor in patients with GORD compared with the blood donating general population. GORD was categorized as nonerosive reflux (NER), erosive oesophagitis, CLO and OAC. The Rotherham Hospital database holds details of all GORD, CLO and OAC patients seen in the Gastroenterology Unit. Blood group information for patients with GORD was obtained from patients' records and the hospital's blood transfusion service. The blood group distribution in the general population was obtained from the National Blood Transfusion Service. The number of expected to observed patients in each blood group for each subtype was compared.Results Two thousand six hundred and ten NER, 2813 erosive oesophagitis, 568 CLO and 73 OAC patients had a recorded blood group. For RhD positive patients observed proportions in each blood group were similar to expected. The most striking difference was the marked excess of OAC in blood group O, Rhesus negative (P = 0.002).Conclusion CLO patients with blood group O, RhD negative carry a disproportionately higher risk of developing OAC. The mechanism is unknown but the finding has practical application in guiding risk stratification and intensity of surveillance. Eur J Gastroenterol Hepatol 23: 801-806 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
|Title:||Barrett's, blood groups and progression to oesophageal cancer: is nitric oxide the link?|
|Keywords:||Barrett's oesophagus, blood groups, nitric oxide, progression to oesophageal cancer, SQUAMOUS-CELL CARCINOMAS, PANCREATIC-CANCER, BREAST-CANCER, PREVALENCE, DISEASE, RISK, ACID|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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