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Selective dielectrophoretic manipulation of surface-immobilized DNA molecules

Germishuizen, WA; Walti, C; Wirtz, R; Johnston, MB; Pepper, M; Davies, AG; Middelberg, APJ; (2003) Selective dielectrophoretic manipulation of surface-immobilized DNA molecules. NANOTECHNOLOGY , 14 (8) 896 - 902.

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The fabrication of nanoscale molecular devices is becoming increasingly important and research into their fabrication has intensified over the last few years. In particular, the attachment of molecular objects onto various surfaces has attracted considerable attention. Here, we report a multistep surface immobilization procedure, which allows the specific and controlled attachment of very long DNA molecules onto gold electrodes. Further, we report the effect of dielectrophoresis on these surface-bound DNA molecules with respect to amplitude and frequency, and we show that selected surface-immobilized DNA molecules can be manipulated by dielectrophoresis. Finally, we investigated the use of dielectrophoresis in conjunction with the multistep surface immobilization of fluorescently labelled, surface-bound lambda-DNA in a basic data-storage device.

Type: Article
Title: Selective dielectrophoretic manipulation of surface-immobilized DNA molecules
UCL classification: UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Engineering Science
URI: http://discovery.ucl.ac.uk/id/eprint/1314365
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