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Current issues and perspectives in hypoplasia of the left heart

Sedmera, D; Cook, AC; Shirali, G; McQuinn, TC; (2005) Current issues and perspectives in hypoplasia of the left heart. CARDIOL YOUNG , 15 (1) 56 - 72. 10.1017/S1047951105000132.

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Abstract

Hypoplastic left heart syndrome is a rare but serious form of congenital cardiac disease, characterized by underdevelopment of the components of the left heart, rendering the left ventricle non-functional. Its aetiology is largely unknown, but there is certainly a genetic component. Prenatal diagnosis nowadays uncovers about half of cases. Postnatal options for treatment include comfort care, 3-stage palliative surgery, or cardiac transplantation. In this review, we discuss the morphology, possible pathogenetic mechanisms, clinical management, and perspectives of prenatal intervention based on work in animal models.

Type: Article
Title: Current issues and perspectives in hypoplasia of the left heart
DOI: 10.1017/S1047951105000132
Publisher version: http://dx.doi.org/10.1017/S1047951105000132
Language: English
Keywords: hypoplasia of left heart, prenatal therapy, growth factors, myocyte proliferation, FIBROBLAST-GROWTH-FACTOR, STEM-CELL TRANSPLANTATION, RESTRICTIVE ATRIAL SEPTUM, BONE-MARROW, CHICK-EMBRYO, NORWOOD PROCEDURE, AORTIC-VALVE, VENTRICULAR MYOARCHITECTURE, ENDOCARDIAL FIBROELASTOSIS, CARDIAC MORPHOGENESIS
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/131178
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