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Platelets, coronary heart disease, and stress

Brydon, L; Magid, K; Steptoe, A; (2006) Platelets, coronary heart disease, and stress. BRAIN BEHAV IMMUN , 20 (2) 113 - 119. 10.1016/j.bbi.2005.08.002.

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Abstract

Coronary heart disease is the leading cause of death in Western society, and its development is associated with chronic stress and other psychosocial factors. Atherosclerosis, the disorder underlying this disease, is an inflammatory process in which leukocytes interact with structurally intact but dysfunctional enclothelium of the arteries. Platelets play a key role in this process by binding to leukocytes and promoting their recruitment to the endothelium. Platelet-leukocyte interactions also stimulate the release of pro-inflammatory and prothrombotic factors which promote atherosclerosis. Elevated circulating levels of platelet-leukocyte aggregates have been reported in cardiac patients and in individuals of low socioeconomic status, a factor associated with chronic psychological stress. Increased platelet activation has also been observed in individuals prone to depression or hostility, and in people subject to high levels of work stress. Acute psychological stress increases circulating platelet-leukocyte aggregates in healthy individuals and this effect is prolonged in cardiac patients. Platelet activation may be a mechanism linking psychosocial stress with increased coronary risk, and may also play a role in the emotional triggering of acute coronary syndromes in patients with advanced coronary disease. (c) 2005 Elsevier Inc. All rights reserved.

Type: Article
Title: Platelets, coronary heart disease, and stress
DOI: 10.1016/j.bbi.2005.08.002
Keywords: platelets, atherosclerosis, acute coronary syndromes, psychological stress, ARTERY-DISEASE, MENTAL STRESS, EXAGGERATED PLATELET, PSYCHOLOGICAL STRESS, HEALTHY CONTROLS, RISK-FACTORS, P-SELECTIN, IN-VIVO, ACTIVATION, REACTIVITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/131167
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