Zeitler, JA; Taday, PF; Pepper, M; Rades, T; (2007) Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy. J PHARM SCI-US , 96 (10) 2703 - 2709. 10.1002/jps.20908.
Full text not available from this repository.
At the example of carbamazepine the crystallization of a small organic molecule from its amorphous phase was studied using in situ variable temperature terahertz pulsed spectroscopy (TPS). Even though terahertz spectra of disordered materials in the glassy state exhibit no distinct spectral features we demonstrate subtle changes in the spectra with increasing temperature and discuss the findings in respect to the density of vibrational states. The crystallization leads to distinct spectral features allowing the crystallization and subsequent polymorphic phase transition at higher temperatures to be studied in detail. It is possible to study both relaxation and crystallization processes by variable temperature TPS. (c) 2007 Wiley-Liss, Inc.
|Title:||Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy|
|Keywords:||terahertz pulsed spectroscopy (TPS), crystallization, amorphous, carbamazepine, phase transition, far infrared, TIME-DOMAIN SPECTROSCOPY, VIBRATIONAL-MODES, STATE, DYNAMICS, CRYSTALLINITY, POLYMORPHISM, LIQUIDS, SYSTEMS, SOLIDS, FORMS|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Electronic and Electrical Engineering|
Archive Staff Only: edit this record