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Antimicrobial treatment of dental osseous defects with silver doped bioglass: Osteoblast cell response

Lohbauer, U; Jell, G; Saravanapavan, P; Jones, JR; Hench, LL; (2005) Antimicrobial treatment of dental osseous defects with silver doped bioglass: Osteoblast cell response. BIOCERAMICS 17 , 17 435 - 438.

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Abstract

In dentistry, chronic periodontitis often leads to bone resorption together with an increasing risk of bacteremia. Bioactive glass has found extensive application as dental graft material. A successful antimicrobial bactericidal effect has been shown from the introduction of Ag2O into the glass composition. In this study, the cytotoxicity of soluble silver, calcium and silica ions on primary human osteoblasts was investigated by measurements of mitochondrial activity and neutral red dye uptake. Silver concentrations of 4 - 6 ppm (1 mg/ml cone.) and 6 9 ppm (2 mg/ml cone.) have been measured in complete culture medium. It was found that the bioactive gel-glass extract with an initial concentration of 1 mg/ml (1 mg glass per ml of culture medium) has no negative effect, whereas increased gel-glass concentration of 2 mg/ml seemed to have a toxic effect on the cell viability of human osteoblasts. It might be concluded that a reduction of the rate of silver dissolution from the bioactive gel-glass might preserve a maximum cell viability.

Type:Article
Title:Antimicrobial treatment of dental osseous defects with silver doped bioglass: Osteoblast cell response
Location:New Orleans, LA
Keywords:antimicrobial, bioactive glass, cytotoxicity, dental, osteoblasts, soluble ions, GLASSES
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery

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