Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.
Cell Death & Disease
, Article e9. 10.1038/cddis.2009.11.
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication. The ATP and its derivatives function as a 'danger signal' in the most primitive forms of life. Purinoceptors are extraordinarily widely distributed in all cell types and tissues and they are involved in the regulation of an even more extraordinary number of biological processes. In addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion, there is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body. In this article, we focus on the latter in the immune/defence system, in stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption, as well as in cancer. Cell Death and Disease (2010) 1, e9; doi:10.1038/cddis.2009.11; published online 14 January 2010
|Title:||Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death|
|Open access status:||An open access version is available from UCL Discovery|
|Additional information:||This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation without specific permission.|
|Keywords:||REFRACTORY PROSTATE-CANCER, ADENOSINE A(1) RECEPTOR, VASCULAR SMOOTH-MUSCLE, KNOCK-OUT MICE, EXTRACELLULAR ATP, P2X RECEPTORS, INTERNATIONAL UNION, NUCLEOTIDE RECEPTOR, IN-VIVO, DICTYOSTELIUM-DISCOIDEUM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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