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The birth and postnatal development of purinergic signalling

Burnstock, G; Fredholm, BB; North, RA; Verkhratsky, A; (2010) The birth and postnatal development of purinergic signalling. ACTA PHYSIOL , 199 (2) 93 - 147. 10.1111/j.1748-1716.2010.02114.x.

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Abstract

The purinergic signalling system is one of the most ancient and arguably the most widespread intercellular signalling system in living tissues. In this review we present a detailed account of the early developments and current status of purinergic signalling. We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions.

Type:Article
Title:The birth and postnatal development of purinergic signalling
DOI:10.1111/j.1748-1716.2010.02114.x
Keywords:adenosine, ATP, co-transmission, history, purinergic signalling, purinoceptors, CENTRAL-NERVOUS-SYSTEM, SMOOTH-MUSCLE-CELLS, GUINEA-PIG ILEUM, ADENOSINE A(1) RECEPTORS, PROTEIN-COUPLED RECEPTOR, RAT VAS-DEFERENS, PAROTID ACINAR-CELLS, DORSAL-HORN NEURONS, GATED ION CHANNELS, INTRACELLULAR CALCIUM-CONCENTRATION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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