Burnstock, G (2009) Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol , 29 (3) 63 - 72. 10.1111/j.1474-8673.2009.00435.x.
Full text not available from this repository.
Abstract
1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. 2 There is dual control of vascular tone by adenosine 5'-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia. 3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation. 4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.
| Type: | Article |
|---|---|
| Title: | Purinergic regulation of vascular tone and remodelling. |
| Location: | England |
| DOI: | 10.1111/j.1474-8673.2009.00435.x |
| Language: | English |
| Keywords: | Adenosine Triphosphate, Animals, Apoptosis, Cell Movement, Cell Proliferation, Humans, Muscle Tonus, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Receptors, Purinergic |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) |
Archive Staff Only: edit this record