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Purinergic regulation of vascular tone and remodelling.

Burnstock, G; (2009) Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol , 29 (3) 63 - 72. 10.1111/j.1474-8673.2009.00435.x.

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1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. 2 There is dual control of vascular tone by adenosine 5'-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia. 3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation. 4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.

Title:Purinergic regulation of vascular tone and remodelling.
Keywords:Adenosine Triphosphate, Animals, Apoptosis, Cell Movement, Cell Proliferation, Humans, Muscle Tonus, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Receptors, Purinergic
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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