Purinergic regulation of vascular tone and remodelling.
Auton Autacoid Pharmacol
63 - 72.
1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. 2 There is dual control of vascular tone by adenosine 5'-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia. 3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation. 4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.
|Title:||Purinergic regulation of vascular tone and remodelling.|
|Keywords:||Adenosine Triphosphate, Animals, Apoptosis, Cell Movement, Cell Proliferation, Humans, Muscle Tonus, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Receptors, Purinergic|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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