UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Purinergic regulation of vascular tone and remodelling.

Burnstock, G; (2009) Purinergic regulation of vascular tone and remodelling. Auton Autacoid Pharmacol , 29 (3) pp. 63-72. 10.1111/j.1474-8673.2009.00435.x.

Full text not available from this repository.


1 Purinergic signalling is involved both in short-term control of vascular tone and in longer-term control of cell proliferation, migration and death involved in vascular remodelling. 2 There is dual control of vascular tone by adenosine 5'-triphosphate (ATP) released from perivascular nerves and by ATP released from endothelial cells in response to changes in blood flow (shear stress) and hypoxia. 3 Both ATP and its breakdown product, adenosine, regulate smooth muscle and endothelial cell proliferation. 4 These regulatory mechanisms are important in pathological conditions, including hypertension, atherosclerosis, restenosis, diabetes and vascular pain.

Type: Article
Title: Purinergic regulation of vascular tone and remodelling.
Location: England
DOI: 10.1111/j.1474-8673.2009.00435.x
Keywords: Adenosine Triphosphate, Animals, Apoptosis, Cell Movement, Cell Proliferation, Humans, Muscle Tonus, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Receptors, Purinergic
URI: http://discovery.ucl.ac.uk/id/eprint/1311098
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item