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P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus

Fu, JQ; Yu, Q; Guo, W; He, C; Burnstock, G; Xiang, ZH; (2009) P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus. NEUROSCI LETT , 458 (1) 32 - 36. 10.1016/j.neulet.2009.04.017.

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Abstract

Expression of P2X(1), P2X(2), P2X(3), P2X(4), P2X(5) and P2X(6) receptors, members of a family of ATP-gated cation channels, on neurons containing luteinizing hormone-releasing hormone (LHRH) in the mouse hypothalamus was studied with double-labeling fluorescence immunohistochemistry. This study demonstrated that different combinations of P2X receptor subunits were expressed on the perikarya and axon terminals of LHRH-producing neurons. It was shown for the first time that P2X(2), P2X(4), P2X(5) and P2Y(6) receptor subunits were expressed on the perikarya of LHRH-producing neurons and P2X(2) and P2X(6) on their axon terminals. These results suggest that activation of P2X receptors by ATP via different homomeric or heteromeric P2X receptors at both presynaptic and postsynaptic sites could be involved in the regulation of LHRH secretion at the forebrain level. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Type:Article
Title:P2X receptors are expressed on neurons containing luteinizing hormone-releasing hormone in the mouse hypothalamus
DOI:10.1016/j.neulet.2009.04.017
Keywords:P2X receptors, ATP, LHRH, Colocalization, Forebrain, Mouse, Hypothalamus, MEDIAL PREOPTIC AREA, NITRIC-OXIDE SYNTHASE, SYNAPTIC CONNECTIONS, SEPTOPREOPTIC AREA, EXTRACELLULAR ATP, NEUROPEPTIDE-Y, RAT, VASOPRESSIN, PHARMACOLOGY, PHYSIOLOGY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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