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Purinergic signalling in the nervous system: an overview

Abbracchio, MP; Burnstock, G; Verkhratsky, A; Zimmermann, H; (2009) Purinergic signalling in the nervous system: an overview. TRENDS NEUROSCI , 32 (1) 19 - 29. 10.1016/j.tins.2008.10.001.

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Abstract

Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling in both peripheral and central nervous systems is a rapidly expanding field. Here, we emphasize purinergic co-transmission, mechanisms of release and breakdown of ATP, ion channel and G-protein-coupled-receptor subtypes for purines and pyrimidines, the role of purines and pyrimidines in neuronglial communication and interactions of this system with other transmitter systems. We also highlight recent data involving purinergic signalling in pathological conditions, including pain, trauma, ischaemia, epilepsy, migraine, psychiatric disorders and drug addiction, which we expect will lead to the development of therapeutic strategies for these disorders with novel mechanisms of action.

Type:Article
Title:Purinergic signalling in the nervous system: an overview
DOI:10.1016/j.tins.2008.10.001
Keywords:OLIGODENDROCYTE PROGENITOR MIGRATION, RAT MEDIAL HABENULA, GATED ION CHANNELS, P2X RECEPTORS, NUCLEOTIDE RECEPTORS, ATP RECEPTOR, SYNAPTIC-TRANSMISSION, EXTRACELLULAR ATP, TASTE-BUDS, FUNCTIONAL EXPRESSION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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