UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Purinergic signalling: past, present and future

Burnstock, G; (2009) Purinergic signalling: past, present and future. Brazilian Journal of Medical and Biological Research , 42 (1) pp. 3-8. Green and gold open access

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
61Kb

Abstract

The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's. The concept of purinergic cotransmission was formulated in 1976 and it is now recognized that ATP is a cotransmitter in all nerves in the peripheral and central nervous systems. Two families of receptors to purines were recognized in 1978, P1 ( adenosine) receptors and P2 receptors sensitive to ATP and adenosine diphosphate ( ADP). Cloning of these receptors in the early 1990's was a turning point in the acceptance of the purinergic signalling hypothesis and there are currently 4 subtypes of P1 receptors, 7 subtypes of P2X ion channel receptors and 8 subtypes of G protein-coupled receptors. Both short-term purinergic signalling in neurotransmission, neuromodulation and neurosecretion and long-term ( trophic) purinergic signalling of cell proliferation, differentiation, motility, death in development and regeneration are recognized. There is now much known about the mechanisms underlying ATP release and extracellular breakdown by ecto-nucleotidases. The recent emphasis on purinergic neuropathology is discussed, including changes in purinergic cotransmission in development and ageing and in bladder diseases and hypertension. The involvement of neuron-glial cell interactions in various diseases of the central nervous system, including neuropathic pain, trauma and ischemia, neurodegenerative diseases, neuropsychiatric disorders and epilepsy are also considered.

Type:Article
Title:Purinergic signalling: past, present and future
Location:Ribeirao Preto, BRAZIL
Open access status:An open access publication. A version is also available from UCL Discovery.
Publisher version:http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso
Language:English
Additional information:This work is published under a Creative Commons Attribution License (CC-BY). The authors retain ownership of the copyright for their article and can allow anyone to download, reuse, reprint, modify, distribute, and/or copy articles published in the BJMBR, as long as the original authors and source are cited. No permission is required from the authors or the publishers.
Keywords:Purinoceptors P1, P2X, P2Y, ATP release and breakdown, Purinergic neuropathology, Pain, Neurodegenerative diseases, CENTRAL-NERVOUS-SYSTEM, GATED ION CHANNELS, GUINEA-PIG, ATP RECEPTOR, ADENOSINE TRIPHOSPHATE, EXTRACELLULAR ATP, TAENIA-COLI, SYNAPTIC TRANSMISSION, MAMMALIAN NEURONS, STRUCTURAL MOTIF
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

View download statistics for this item

Archive Staff Only: edit this record