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EXPRESSION OF P2X(5) RECEPTORS IN THE MOUSE CNS

Guo, W; Xu, X; Gao, X; Burnstock, G; He, C; Xiang, Z; (2008) EXPRESSION OF P2X(5) RECEPTORS IN THE MOUSE CNS. NEUROSCIENCE , 156 (3) 673 - 692. 10.1016/j.neuroscience.2008.07.062.

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Abstract

P2X receptors are ATP-gated cationic channels composed of seven known subunits (P2X(1-7)) which are involved in different functions in neural tissue. The present study investigates the P2X(5) receptor expression pattern in the mouse CNS using immunohistochemistry and in situ hybridization histochemistry. The specificity of the immunostaining has been verified by pre-absorption, Western blot and in situ hybridization methods. Heavy P2X(5) receptor immunostaining was observed in the mitral cells of the olfactory bulb; cerebral cortex; globus pallidum, anterior cortical amygdaloid nucleus, amygdalohippocampal area of subcortical telencephalon; anterior nuclei, anteroventral nucleus, ventrolateral nucleus of thalamus; supraoptic nucleus, ventromedial nucleus, arcuate nucleus of hypothalamus; substantia nigra of midbrain; pontine nuclei, mesencephalic trigeminal nucleus, motor trigeminal nucleus, ambiguous nucleus, inferior olive, hypoglossal nucleus, dorsal motor vagus nucleus, area postrema of hindbrain; Purkinje cells of cerebellum; and spinal cord. The identification of extensive P2X(5) receptor immunoreactivity and mRNA distribution within the CNS of the mouse demonstrated here is consistent with a role for extracellular ATP acting as a fast neurotransmitter. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

Type:Article
Title:EXPRESSION OF P2X(5) RECEPTORS IN THE MOUSE CNS
DOI:10.1016/j.neuroscience.2008.07.062
Keywords:P2X(5) receptor, immunohistochemistry, in situ hybridization, CNS, NUCLEUS-TRACTUS-SOLITARIUS, CENTRAL-NERVOUS-SYSTEM, GATED ION CHANNELS, RAT HYPOTHALAMONEUROHYPOPHYSEAL SYSTEM, SUPRAOPTIC VASOPRESSIN CELLS, ATP RECEPTOR, POSTNATAL-DEVELOPMENT, EXTRACELLULAR ATP, NEURONS, PURINOCEPTORS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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