UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Unresolved issues and controversies in purinergic signalling

Burnstock, G; (2008) Unresolved issues and controversies in purinergic signalling. J PHYSIOL-LONDON , 586 (14) 3307 - 3312. 10.1113/jphysiol.2008.155903.

Full text not available from this repository.

Abstract

Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.

Type: Article
Title: Unresolved issues and controversies in purinergic signalling
DOI: 10.1113/jphysiol.2008.155903
Keywords: P2X(7) RECEPTOR FUNCTION, NEUROPATHIC PAIN, SENSORY NEURONS, CELL-PROLIFERATION, NERVOUS-SYSTEM, UP-REGULATION, STEM-CELLS, ATP, ALLODYNIA, MICROGLIA
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1311071
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item