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Unresolved issues and controversies in purinergic signalling

Burnstock, G; (2008) Unresolved issues and controversies in purinergic signalling. J PHYSIOL-LONDON , 586 (14) 3307 - 3312. 10.1113/jphysiol.2008.155903.

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Abstract

Some areas of current interest in the rapidly expanding purinergic signalling field that are controversial or are unresolved are highlighted in this review. These include the mechanisms underlying: ATP transport across cell and vesicle membranes; the interaction of multiple receptors for purines and pyrimidines on single cells; the blocking effect of antagonists to P2X(4) and P2X(7) receptors expressed by microglial cells in neuropathic and inflammatory pain; and the complex actions mediated by P2X(7) receptors. Some desirable areas for further research are also discussed including: comparative studies of the evolution of purinergic signalling; studies of purinergic signalling in development and regeneration, including the involvement of stem cells; behavioural studies; and therapeutic strategies.

Type:Article
Title:Unresolved issues and controversies in purinergic signalling
DOI:10.1113/jphysiol.2008.155903
Keywords:P2X(7) RECEPTOR FUNCTION, NEUROPATHIC PAIN, SENSORY NEURONS, CELL-PROLIFERATION, NERVOUS-SYSTEM, UP-REGULATION, STEM-CELLS, ATP, ALLODYNIA, MICROGLIA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)

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