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Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide

Whiteman, M; Gooding, KM; Whatmore, JL; Ball, CI; Mawson, D; Skinner, K; Tooke, JE; (2010) Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. DIABETOLOGIA , 53 (8) 1722 - 1726. 10.1007/s00125-010-1761-5.

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Abstract

Hydrogen sulphide is a recently identified endogenous endothelium-dependent vasodilator. Animal models of diabetes have shown that low plasma H2S levels are associated with marked endothelial dysfunction and insulin resistance. However, human studies on H2S and vascular function in health and disease are lacking.Plasma was obtained from male patients with type 2 diabetes (n = 11), overweight (n = 16) and lean (n = 11) volunteers. H2S levels were determined by zinc trap spectrophotometry. Anthropometric measurements (BMI/waist:hip ratio), lipid profile, systemic blood pressure, biochemical indices of diabetes (fasting glucose, insulin sensitivity, Hb(1Ac)) and microvascular function (minimum vascular resistance) were determined.Median plasma H2S levels (25th, 75th percentiles) in age-matched lean, overweight and type 2 diabetes individuals were 38.9 (29.7, 45.1) A mu mol/l, 22.0 (18.6, 26.7) A mu mol/l and 10.5 (4.8, 22.0) A mu mol/l, respectively. Median plasma H2S levels were significantly lower in patients with type 2 diabetes compared with lean (p = 0.001, Mann-Whitney) and overweight participants (p = 0.008). Median plasma H2S levels in overweight participants were significantly lower than in lean controls (p = 0.003). Waist circumference was an independent predictor of plasma H2S (R (2) = 0.423, standardised beta: -0.650, p < 0.001). This relationship was independent of diabetes, which only contributed a further 5% to the model (R (2) = 0.477). Waist circumference or other measures of adiposity (waist:hip ratio/BMI) remained independent predictors of plasma H2S after adjustment for systolic blood pressure, microvascular function, insulin sensitivity, glycaemic control and lipid profile.Plasma H2S levels are reduced in overweight participants and patients with type 2 diabetes. Increasing adiposity is a major determinant of plasma H2S levels.

Type: Article
Title: Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide
DOI: 10.1007/s00125-010-1761-5
Keywords: Hydrogen sulphide, Vasodilator, Adiposity, Diabetes, Microcirculation, NITRIC-OXIDE, BIOSYNTHESIS, CELLS, H2S
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > VP Health
UCL > Provost and Vice Provost Offices > VP Health > SLMS Partnerships and Projects
URI: http://discovery.ucl.ac.uk/id/eprint/1310890
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