TURNER, RC and HOLMAN, RR and MATTHEWS, DR and BASSETT, PA and COSTER, R and STRATTON, IM and CULL, CA and PETO, R and FRIGHI, V and KENNEDY, IA and MANLEY, SE and BOWN, EG and EELEY, EA and ROSS, I and MATTHEWS, DR and DORNAN, TL and WRIGHT, AD and NEIL, HAW and KOHNER, EM and ALDINGTON, S and KEEN, N and ROSE, C and FLETCHER, AE and BATTERSBY, C and YUDKIN, JS and OAKES, SF and TURNER, RC and HOLMAN, RR and STEARN, MR and PALMER, SL and HAMMERSLEY, MS and FRANKLIN, SL and SPIVEY, RS and HOCKADAY, TDR and MURCHISON, LE and BRUNT, AHE and WILLIAMS, MJ and MACPEARSON, DW and PETRIE, XMP and LEAN, MEJ and WRIGHT, AD and LEVI, NA and SHEARER, ACI and THOMPSON, RJW and KOHNER, EM and DODDRIDGE, MC and HAYES, JR and HENRY, RW and FETHERSTON, MS and HADDEN, DR and KENNEDY, L and ATKINSON, AB and CULBERT, AM and HAGAN, C and SPATHIS, AS and NANSON, ME and JAMES, LM and TYRELL, JM and YUDKIN, JS and GOULD, C and SINGER, J and BADENOCH, M and GREENWOOD, RH and WILSON, J and DENHOLM, MJ and TEMPLE, RC and BORTHWICK, LJ and WHEATCROFT, DJ and SEAMAN, RJ and CHRISTIE, RA and NEWTON, RW and JUNG, RT and ROXBURGH, C and KILGALLAN, B and FOX, CJ and HOLLOWAY, MC and COGHILL, HM and PAISEY, RB and BROWN, NPR and TUCKER, AJ and ROLAND, JM and BROWN, DJ and YOUENS, J and BROWN, PM and DAVIDSON, AJM and PEACOCK, IDA and CULVERWELL, NJC and CHARLTON, MH and CONNOLLY, BPS and BOULTON, AJM and ROBERTSON, AM and YOUNG, RJ and DORNAN, TL and CLYNE, JR and BURDEN, AC and SELLEN, EM and TOOKE, JE (1993) HYPERTENSION IN DIABETES STUDY (HDS) .1. PREVALENCE OF HYPERTENSION IN NEWLY PRESENTING TYPE-2 DIABETIC-PATIENTS AND THE ASSOCIATION WITH RISK-FACTORS FOR CARDIOVASCULAR AND DIABETIC COMPLICATIONS. J HYPERTENS , 11 (3) 309 - 317.
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Objective: To determine the prevalence of hypertension in newly diagnosed type 2 diabetic patients and its association with risk factors for cardiovascular and diabetic complications.Design: Cross-sectional study.Patients: Newly diagnosed type 2 diabetic patients (n = 3648, mean age 52 years, 59% male) recruited for the UK Prospective Diabetes Study (UKPDS).Measurements: Blood pressure, body mass index, waist:hip ratio, ECG signs of ischaemia and of left ventricular hypertrophy (Minnesota code), fasting plasma glucose, urate, creatinine, insulin, triglycerides, high-density lipoprotein-, low-density lipoprotein- and total cholesterol, urinary albumin: creatinine ratio, retinopathy grading.Results: Thirty-nine per cent of the patients (35% of the males, 46% of the females) were hypertensive (mean blood pressure greater-than-or-equal-to 160 systolic and/or greater-than-or-equal-to 90 mmHg diastolic 2 and 9 months after diagnosis of diabetes, or taking antihypertensive therapy). The hypertensive patients had a greater mean body mass index (30.1 versus 28.0 kg/m2, P < 0.0001) than the normotensive patients. They also had higher fasting plasma triglyceride (1.94 versus 1.69 mmol/l, P < 0.0001) and insulin (15.0 versus 12.8 mU/l, P < 0.0001) levels but these associations disappeared or weakened when obesity was taken into account. Hypertensive compared with normotensive subjects suffered a higher prevalence of cardiovascular events before the diagnosis of diabetes (4.8 versus 2.5%, P < 0.0001), of microalbuminuria (albumin: creatinine ratio > 5.0 g/mol; 24 versus 14%, P < 0.0001), of ECG signs of probable and possible ischaemia (24 versus 14%, P < 0.0001) and of left ventricular hypertrophy (8.5 versus 3.8%; P < 0.0001). The prevalence of retinopathy was similar in the two groups.Conclusions: Hypertension is common in newly diagnosed type 2 diabetes and is associated with obesity. The association between hypertension and higher triglyceride and insulin levels may be secondary to obesity in this population. An association between hypertension and cardiovascular complications is already apparent at diagnosis of diabetes.
|Title:||HYPERTENSION IN DIABETES STUDY (HDS) .1. PREVALENCE OF HYPERTENSION IN NEWLY PRESENTING TYPE-2 DIABETIC-PATIENTS AND THE ASSOCIATION WITH RISK-FACTORS FOR CARDIOVASCULAR AND DIABETIC COMPLICATIONS|
|Keywords:||TYPE-2 DIABETES, HYPERTENSION, ANTIHYPERTENSIVE THERAPY, ECG, TRIGLYCERIDE, HIGH-DENSITY LIPOPROTEIN-CHOLESTEROL, INSULIN, URATE, EPIDEMIOLOGY, UK PROSPECTIVE DIABETES STUDY, CORONARY-HEART-DISEASE, LEFT-VENTRICULAR MASS, BLOOD-PRESSURE, INSULIN RESISTANCE, GLUCOSE-TOLERANCE, URINARY ALBUMIN, MORTALITY, POPULATION, MELLITUS, SERUM|
|UCL classification:||UCL > School of Life and Medical Sciences|
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