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Effects of a selective partial D1 agonist, CY 208-243, in de novo patients with Parkinson disease.

Emre, M; Rinne, UK; Rascol, A; Lees, A; Agid, Y; Lataste, X; (1992) Effects of a selective partial D1 agonist, CY 208-243, in de novo patients with Parkinson disease. Mov Disord , 7 (3) pp. 239-243. 10.1002/mds.870070309.

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Abstract

A selective dopamine D1-receptor agonist, CY 208-243, was administered to 23 de novo patients who had had Parkinson disease (PD) for less than or equal to 3 months. The drug was first used as monotherapy and then in some patients in combination with a dopamine D2-receptor agonist, bromocriptine. Results showed that CY 208-243 exerted a mild antiparkinsonian action, and tremor was the main symptom that consistently improved. The addition of bromocriptine less than or equal to 15 mg to CY 208-243 did not result in additional improvement, but this might be due to the short duration of treatment and the low doses of bromocriptine. The study was prematurely discontinued for safety reasons. We conclude that D1-receptor stimulation may result in improvement of motor disability in PD.

Type: Article
Title: Effects of a selective partial D1 agonist, CY 208-243, in de novo patients with Parkinson disease.
Location: United States
DOI: 10.1002/mds.870070309
Keywords: Adult, Aged, Antiparkinson Agents, Bromocriptine, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Female, Humans, Indoles, Male, Middle Aged, Neurologic Examination, Parkinson Disease, Phenanthridines, Receptors, Dopamine, Receptors, Dopamine D1
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1310055
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