Kristo, AS; Kalea, AZ; Schuschke, DA; Klimis-Zacas, DJ; (2010) A Wild Blueberry-Enriched Diet (Vaccinium angustifolium) Improves Vascular Tone in the Adult Spontaneously Hypertensive Rat. J AGR FOOD CHEM , 58 (22) 11600 - 11605. 10.1021/jf101839u.
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The effect of a wild blueberry-enriched diet on vasoconstriction and vasorelaxation was examined in the adult, 20-week-old spontaneously hypertensive rat (SHR) after 8 weeks of a control (C) or an 8% wild blueberry (WB) diet. Nitric oxide (NO)- and cyclooxygenase (COX)-mediated aortic responses were examined ex vivo with the agonists L-phenylephrine (Phe) and acetylcholine (Ach), in the absence or presence of the NO synthase (NOS) inhibitor L-N-G-monomethyl arginine (L-NMMA) or the COX inhibitor mefenamic acid (MFA). The vasoconstriction elicited by Phe was reduced in the WB group, attributed to the NO pathway, favoring a lower vascular tone under basal conditions. Acetylcholine-induced vasorelaxation in the WB group was possibly mediated through the COX, but not the NO pathway. These findings document the potential of wild blueberries to modify major pathways of vasomotor control and improve the vascular tone in the adult SHR with endothelial dysfunction.
|Title:||A Wild Blueberry-Enriched Diet (Vaccinium angustifolium) Improves Vascular Tone in the Adult Spontaneously Hypertensive Rat|
|Keywords:||Spontaneously hypertensive rat, wild blueberry, Vaccinium angustifolium, vasoconstriction, vasorelaxation, SPRAGUE-DAWLEY RAT, ENDOTHELIUM-DEPENDENT VASORELAXATION, OXIDATIVE STRESS, FLAVONOID QUERCETIN, THORACIC AORTA, DYSFUNCTION, REACTIVITY, CONTRACTIONS, RESVERATROL, CONSUMPTION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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