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Cellular and molecular mechanisms of inflammation and thrombosis

Tan, P; Luscinskas, FW; Homer-Vanniasinkam, S; (1999) Cellular and molecular mechanisms of inflammation and thrombosis. EUR J VASC ENDOVASC , 17 (5) 373 - 389.

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Abstract

In the last 20 years, the cellular and molecular mechanisms of inflammation and thrombosis have been characterised. These ave essentially cell adhesion processes which are regulated by vascular endothelium. Many of the cell adhesion molecules and leucocyte chemoattractants expressed and generated at sites of inflammation have been sequenced and cloned. These inflammatory molecules work together in concert to mediate the adhesion between leucocytes, platelets and vascular endothelium which occurs during the occlusive, thromboembolic, reperfusion and septic complications of atherosclerotic and diabetic vascular diseases. This review aims to summarise our current understanding of the molecular basis of these disorders and the therapeutic implications.

Type:Article
Title:Cellular and molecular mechanisms of inflammation and thrombosis
Keywords:cell adhesion molecules, chemokines, neutrophils, inflammation, atherosclerosis, thrombosis, HUMAN-ENDOTHELIAL-CELLS, INTERCELLULAR-ADHESION MOLECULE-1, PLATELET-ACTIVATING-FACTOR, TUMOR-NECROSIS-FACTOR, MONOCYTE CHEMOTACTIC PROTEIN-1, SELECTIN-DEFICIENT MICE, HUMAN MESOTHELIAL CELLS, SMOOTH-MUSCLE CELLS, LEUKOCYTE ADHESION, P-SELECTIN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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