Kumar, S;
Stephan, KE;
Warren, JD;
Friston, KJ;
Griffiths, TD;
(2007)
Hierarchical processing of auditory objects in humans.
PLOS COMPUT BIOL
, 3
(6)
, Article e100. 10.1371/journal.pcbi.0030100.
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Abstract
This work examines the computational architecture used by the brain during the analysis of the spectral envelope of sounds, an important acoustic feature for defining auditory objects. Dynamic causal modelling and Bayesian model selection were used to evaluate a family of 16 network models explaining functional magnetic resonance imaging responses in the right temporal lobe during spectral envelope analysis. The models encode different hypotheses about the effective connectivity between Heschl's Gyrus (HG), containing the primary auditory cortex, planum temporale (PT), and superior temporal sulcus (STS), and the modulation of that coupling during spectral envelope analysis. In particular, we aimed to determine whether information processing during spectral envelope analysis takes place in a serial or parallel fashion. The analysis provides strong support for a serial architecture with connections from HG to PT and from PT to STS and an increase of the HG to PT connection during spectral envelope analysis. The work supports a computational model of auditory object processing, based on the abstraction of spectro-temporal ''templates'' in the PT before further analysis of the abstracted form in anterior temporal lobe areas.
| Type: | Article |
|---|---|
| Title: | Hierarchical processing of auditory objects in humans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pcbi.0030100 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pcbi.0030100 |
| Language: | English |
| Additional information: | © 2007 Kumar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The work is supported by a Wellcome Trust Grant awarded to TDG. JDW was supported by a Wellcome Trust Intermediate Clinical Fellowship. |
| Keywords: | DYNAMIC CAUSAL-MODELS, EFFECTIVE CONNECTIVITY, CORTICAL INTERACTIONS, GRANGER CAUSALITY, BALLOON MODEL, CORTEX, FMRI, SYSTEM, BRAIN, LATERALIZATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/130955 |
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