UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia

Mortimer, AM; Joyce, E; Balasubramaniam, K; Choudhary, PC; Saleem, PT; SOLIANOL Study Grp, ; (2007) Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. HUM PSYCHOPHARM CLIN , 22 (7) 445 - 454. 10.1002/hup.865.

Full text not available from this repository.

Abstract

Objectives Although antipsychotic drugs control acute psychotic manifestations of schizophrenia, improving cognitive symptoms is also important for long-term prognosis.Methods Three hundred and seventy-seven adult patients with acute psychosis were randomised to either amisulpride (200-800 mg/d) or olanzapine (5-20 mg/d) for 6 months. Neuropsychological performance was assessed at inclusion and after 6 months in a subgroup of 26 subjects (I I treated with amisulpride and 15 with olanzapine) using the Auditory Verbal Learning Test (AVLT), the Trail Making Test (TMT) and the Controlled Oral Word Association Test (COWAT).Results The improvement in BPRS score was similar in both treatment groups. No significant differences in test performance between groups were observed at inclusion. After 6months, AVLT scores increased by 8.7 points in the amisulpride group and by 2.3 points in the olanzapine group (p = 0.049). Completion speed in the TMT increased by 17.4 s (amisulpride) and 15.4 s (olanzapine) for Part A and by 39.8 and 48.8 s, respectively for Part B. Performance in the COWAT improved little in both groups.Conclusions Both amisulpride and olanzapine produce sustained improvement in certain measures of neuropsychologlical performance in patients with schizophrenia; a significant improvement in score on the AVLT was observed only with amisulpride. Copyright (c) 2007 John Wiley & Sons, Ltd.

Type: Article
Title: Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia
DOI: 10.1002/hup.865
Keywords: amisulpride, olanzapine, schizophrenia, cognitive function, neuropsychological testing, RANDOMIZED CONTROLLED-TRIALS, COGNITIVE FUNCTION, NEUROCOGNITIVE DEFICITS, DOUBLE-BLIND, RISPERIDONE, METAANALYSIS, HALOPERIDOL, IMPAIRMENT, CLOZAPINE, ANTIPSYCHOTICS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1309388
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item