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Oxidative stress in obstructive nephropathy

Dendooven, A; Ishola, DA; Nguyen, TQ; Van der Giezen, DM; Kok, RJ; Goldschmeding, R; Joles, JA; (2011) Oxidative stress in obstructive nephropathy. INT J EXP PATHOL , 92 (3) 202 - 210. 10.1111/j.1365-2613.2010.00730.x.

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Abstract

P>Unilateral ureteric obstruction (UUO) is one of the most commonly applied rodent models to study the pathophysiology of renal fibrosis. This model reflects important aspects of inflammation and fibrosis that are prominent in human kidney diseases. In this review, we present an overview of the factors contributing to the pathophysiology of UUO, highlighting the role of oxidative stress.

Type: Article
Title: Oxidative stress in obstructive nephropathy
DOI: 10.1111/j.1365-2613.2010.00730.x
Keywords: NADPH oxidase, oxidative stress, renal disease, unilateral ureteric obstruction, UNILATERAL URETERAL OBSTRUCTION, RENAL TUBULOINTERSTITIAL FIBROSIS, NITRIC-OXIDE SYNTHASE, CHRONIC GRANULOMATOUS-DISEASE, BONE MORPHOGENETIC PROTEINS, SALT-SENSITIVE HYPERTENSION, OXYGEN SPECIES PRODUCTION, NADPH OXIDASE, INTERSTITIAL FIBROSIS, NAD(P)H OXIDASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Health Informatics > Infectious Disease Informatics
URI: http://discovery.ucl.ac.uk/id/eprint/1309362
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