Carrey, EA; Smolenski, RT; Edbury, SM; Laurence, A; Marinaki, AM; Duley, JA; ... Simmonds, HA; + view all Carrey, EA; Smolenski, RT; Edbury, SM; Laurence, A; Marinaki, AM; Duley, JA; Zhu, LM; Goldsmith, DJA; Simmonds, HA; - view fewer (2004) An unusual pyridine nucleotide accumulating in erythrocytes: Its identity and positive correlation with degree of renal failure. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS , 23 (8-9) 1135 - 1139. 10.1081/NCN-200027391.
Full text not available from this repository.
We have investigated an unusual nucleotide that accumulates, with precursors, in the erythrocytes of patients in uraemia. This nucleotide is related chemically to the NAD breakdown product, N1-methyl-2-pyridone-5-carboxamide (Me2Py), found in high concentrations in the plasma of uraemic patients. Both Me2Py and the nucleotide accumulate to high concentrations in the blood during uraemia: our investigations of samples from renal out-patients have provided information on a plausible link between the two compounds.
|Title:||An unusual pyridine nucleotide accumulating in erythrocytes: Its identity and positive correlation with degree of renal failure|
|Location:||Egmond Aan Zee, NETHERLANDS|
|Keywords:||N1-methyl-2-pyridone-5-carboxamide (Me2Py), uraemia, pyridine nucleotide, HPLC, LC/MS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > ICH - General Administration > ICH - Directors Office|
Archive Staff Only: edit this record