Jones, AWE and Szabadkai, G (2010) Ca2+ Transfer from the ER to Mitochondria: Channeling Cell Death by a Tumor Suppressor. DEV CELL , 19 (6) 789 - 790. 10.1016/j.devcel.2010.11.013.
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Abstract
The mitochondrial gateway to cell death is a frequent target for tumor suppressors, which largely utilize Bcl-2-dependent apoptotic pathways. Reporting in Science, Giorgi et al. (2010) now show that PML exerts its tumor suppressor function via a distinct mechanism: Ca2+ transfer from the endoplasmic reticulum to the mitochondria.
| Type: | Article |
|---|---|
| Title: | Ca2+ Transfer from the ER to Mitochondria: Channeling Cell Death by a Tumor Suppressor |
| DOI: | 10.1016/j.devcel.2010.11.013 |
| Keywords: | PERMEABILITY TRANSITION, APOPTOSIS, BAD |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of) > Cell and Developmental Biology |
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