UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Beginning-of-dose motor deterioration following the acute administration of levodopa and apomorphine in Parkinson's disease.

Merello, M; Lees, AJ; (1992) Beginning-of-dose motor deterioration following the acute administration of levodopa and apomorphine in Parkinson's disease. J Neurol Neurosurg Psychiatry , 55 (11) pp. 1024-1026. 10.1136/jnnp.55.11.1024.

Full text not available from this repository.

Abstract

Six Parkinsonian patients on long term levodopa therapy complained of short-lived deterioration of Parkinsonian symptoms immediately after levodopa intake. After withdrawal of the drug overnight, and following an oral challenge with levodopa/carbidopa (250/25) in all six cases, and with subcutaneous apomorphine (3 mg) in two, deterioration below base line levels of disability were observed which would not be explained by loss of sleep benefit. This occurred 10-20 minutes after levodopa challenge and lasted for 10-20 minutes. The latency and duration of this phenomenon were shorter with apomorphine but the characteristics were similar. This phenomenon may be due to an inhibitory effect of levodopa acting via presynaptic dopamine receptors.

Type: Article
Title: Beginning-of-dose motor deterioration following the acute administration of levodopa and apomorphine in Parkinson's disease.
Location: England
DOI: 10.1136/jnnp.55.11.1024
Keywords: Adult, Apomorphine, Female, Humans, Injections, Subcutaneous, Levodopa, Male, Middle Aged, Movement Disorders, Parkinson Disease
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1308624
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item