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Cardiovascular reflexes in Parkinson's disease: effect of domperidone and apomorphine.

Merello, M; Pirtosek, Z; Bishop, S; Lees, AJ; (1992) Cardiovascular reflexes in Parkinson's disease: effect of domperidone and apomorphine. Clin Auton Res , 2 (4) pp. 215-219.

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Abstract

Cardiovascular reflexes were evaluated in 18 patients with idiopathic Parkinson's disease who had a Hoehn & Yahr score of III-IV. The effect of apomorphine and domperidone on blood pressure, heart rate, R-R interval variation, and the Valsalva ratio were studied. Autonomic dysfunction was not found in the patients and there were no differences between subgroups of patients on different treatments. Apomorphine altered cardiovascular reflexes to a greater degree in patients who received the drug for the first time than in chronically treated patients. The changes were antagonized by domperidone, a peripheral dopamine receptor antagonist. Apomorphine treated patients who were receiving long-term domperidone had similar abnormalities of cardiovascular reflexes to those who had been able to withdraw it.

Type: Article
Title: Cardiovascular reflexes in Parkinson's disease: effect of domperidone and apomorphine.
Location: Germany
Keywords: Aged, Apomorphine, Blood Pressure, Domperidone, Female, Heart Rate, Humans, Male, Middle Aged, Parkinson Disease
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1308620
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