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A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RAR alpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia

Langabeer, SE; Grimwade, D; Walker, H; Rogers, JR; Burnett, AK; Goldstone, AH; Linch, DC; (1998) A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RAR alpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia. BRIT J HAEMATOL , 101 (2) 338 - 340.

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Abstract

Acute myeloid leukaemia (AML) patients with either a t(15;17), t(8;21) or inv(16) at diagnosis have 'good-risk' disease with a favourable response to therapy and improved survival. Detection of cryptic fusion genes created by these translocations has been reported where there is no cytogenetic evidence of the corresponding abnormality. It is likely that these cases share the same favourable prognosis. Secondary cytogenetic changes commonly associated with these rearrangements are +8 with t(15;17), del(9q) with t(8;21) and +22 with inv(16). These secondary abnormalities are also observed alone, raising the possibility that they may be markers of underlying cryptic rearrangements. In order to determine the frequency of these rearrangements in AML cases with +8, del(9q) or +22 we have performed an analysis of 63 such patients in whom there was no evidence of a t(15;17), t(8;21) or inv(16) by cytogenetics. No disease-related fusion transcripts were identified, indicating that the secondary changes are rarely markers for cryptic rearrangements.

Type: Article
Title: A study to determine whether trisomy 8, deleted 9q and trisomy 22 are markers of cryptic rearrangements of PML/RAR alpha, AML1/ETO and CBFB/MYH11 respectively in acute myeloid leukaemia
Keywords: AML, cytogenetics, cryptic rearrangements, secondary abnormalities, ACUTE PROMYELOCYTIC LEUKEMIA, CYTOGENETICS, MORPHOLOGY, TRANSCRIPT, TRIAL, GENE, AML
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1308318
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