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Mismatch negativity potentials and cognitive impairment in schizophrenia

Baldeweg, T; Klugman, A; Gruzelier, J; Hirsch, SR; (2004) Mismatch negativity potentials and cognitive impairment in schizophrenia. SCHIZOPHR RES , 69 (2-3) 203 - 217. 10.1016/j.schres.2003.09.009.

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Abstract

Cognitive impairment in schizophrenia is an important predictor of clinical and social outcome. In this preliminary study, the correlation between cognitive status and deficits in mismatch negativity (MMN) generation was explored. The MMN response to tone duration deviants was recorded using a new stimulation protocol with continuously changing ('roving') standard stimuli in order to measure the effect of standard repetitions on MMN (memory trace effect). Cognitive status of the patient group (n=28) was assessed using neuropsychological screening. Healthy participants (n=20) served as age-matched comparison group.In patients, MMN amplitude in frontal electrodes as well as the MM memory trace effect was diminished compared to controls. While both measures were inversely related to patient's age and disease severity, only the MMN memory trace effect was robustly correlated with the degree of neuropsychological impairment. This suggests that ERP measures of auditory system adaptability more appropriately characterise the pathophysiological processes underlying cognitive impairment in schizophrenia than static measures of ERP magnitude. (C) 2003 Elsevier B.V. All rights reserved.

Type: Article
Title: Mismatch negativity potentials and cognitive impairment in schizophrenia
DOI: 10.1016/j.schres.2003.09.009
Keywords: schizophrenia, mismatch negativity (MMN), event-related potentials (ERP), auditory sensory memory, cognition, neuropsychology, AUDITORY SENSORY MEMORY, ECHOIC MEMORY, 1ST-EPISODE SCHIZOPHRENIA, TEMPORAL DISCRIMINATION, HEALTHY-VOLUNTEERS, STIMULUS DEVIANCE, BRAIN, GENERATION, DYSFUNCTION, ATTENTION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: http://discovery.ucl.ac.uk/id/eprint/130827
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