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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

Jimenez, C; Jones, DR; Rodriguez-Viciana, P; Gonzalez-Garcia, A; Leonardo, E; Wennstrom, S; von Kobbe, C; ... Carrera, AC; + view all (1998) Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J , 17 (3) 743 - 753.

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Abstract

p85/p110 phosphoinositide 3-kinase (PI3K) is a heterodimer composed of a p85-regulatory and a p110-catalytic subunit, which is involved in a variety of cellular responses including cytoskeletal organization, cell survival and proliferation. We describe here the cloning and characterization of p65-PI3K, a mutant of the regulatory subunit of PI3K, which includes the initial 571 residues of the wild type p85 alpha-protein linked to a region conserved in the eph tyrosine kinase receptor family. We demonstrate that this mutation, obtained from a transformed cell, unlike previously engineered mutations of the regulatory subunit, induces the constitutive activation of PI3K and contributes to cellular transformation. This report links the PI3K enzyme to mammalian tumor development for the first time.

Type: Article
Title: Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
Keywords: mutants, phosphatidylinositol 3-kinase, transformation, RECEPTOR TYROSINE KINASES, PHOSPHATIDYLINOSITOL 3-KINASE, PROTEIN-KINASE, P85-ALPHA GENE, CDNA CLONING, SH2 DOMAINS, ACTIVATION, BINDING, P85, INSULIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: http://discovery.ucl.ac.uk/id/eprint/1308034
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