Kodaki, T; Woscholski, R; Hallberg, B; Rodriguez-Viciana, P; Downward, J; Parker, PJ; (1994) The activation of phosphatidylinositol 3-kinase by Ras. Curr Biol , 4 (9) 798 - 806.
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Activation of the mammalian phosphatidylinositol 3-kinase complex can play a critical role in transducing growth factor responses. The lipid kinase complex, which is made up of p85 alpha and p110 alpha regulatory and catalytic subunits, becomes associated with a number of activated receptor protein tyrosine kinases, but the mechanism of its activation has not yet been defined. Recent evidence indicates that Ras can bind to the p85 alpha/p110 alpha complex. We describe here the functional regulation of the mammalian phosphatidylinositol 3-kinase complex by Ras.
|Title:||The activation of phosphatidylinositol 3-kinase by Ras.|
|Keywords:||Animals, Cattle, Enzyme Activation, Gene Expression, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), Protein Conformation, Schizosaccharomyces, Signal Transduction, ras Proteins|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology|
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