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PLATELET VON-WILLEBRAND-FACTOR AND BLEEDING IN CHRONIC-RENAL-FAILURE

ROBINSON, G; TALBOT, S; CHITOLIE, A; BOND, L; WEBB, DJ; EASTWOOD, JB; (1995) PLATELET VON-WILLEBRAND-FACTOR AND BLEEDING IN CHRONIC-RENAL-FAILURE. J NEPHROL , 8 (1) 41 - 44.

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Abstract

Twenty patients with stable chronic renal failure were studied to investigate the role of von Willebrand factor (vWf) in the bleeding tendency seen in uremia. A subgroup of six patients (30%) with an abnormal platelet vWf multimer pattern consisting of greatly reduced intermediate and high molecular weight multimers was identified. More of these patients reported easy bruising or bleeding (p < 0.05) when compared with uremic patients with a normal platelet vWf pattern, and bleeding time also appeared to be prolonged in this group. The expected overall positive correlation between plasma vWf antigen level and creatinine was seen (r = 0.63, p < 0.005). The pattern of plasma vWf multimers did not differ significantly from normal in any of the patients studied. These findings suggest that deficiency of intermediate and high molecular weight vWf multimers in platelets may make an important contribution to the increased tendency of uremic individuals to bleed.

Type: Article
Title: PLATELET VON-WILLEBRAND-FACTOR AND BLEEDING IN CHRONIC-RENAL-FAILURE
Keywords: CHRONIC RENAL FAILURE, HEMOSTASIS, PLATELETS, VON WILLEBRAND FACTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1307997
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