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Un modello di analisi del valore dell'informazione per la valutazione di costo-efficacia nell'ambito del processo regolatorio

Baio, G; Russo, P; (2010) Un modello di analisi del valore dell'informazione per la valutazione di costo-efficacia nell'ambito del processo regolatorio. PharmacoEconomics - Italian Research Articles , 12 (1) 5 - 16.

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Abstract

Cost-effectiveness analysis (CEA) represents the most important tool in the health economics literature to quantify and qualify the reasoning behind the optimal decision process in terms of the allocation of resources to a given health intervention. However, the practical application of CEA in the regulatory process is often limited by some critical barriers, and decisions in clinical practice are frequently influenced by factors that do not contribute to efficient resource allocation, leading to inappropriate drug prescription and utilization. Moreover, most of the time there is uncertainty about the real cost-effectiveness profile of an innovative intervention, with the consequence that it is usually impossible to obtain an immediate and perfect substitution of a product with another having a better cost-effectiveness ratio. The objective of this article is to propose a rational approach to CEA within regulatory processes, basing our analysis in a Bayesian decision-theoretic framework and proposing an extension of the application of well known tools (such as the expected value of information) to such cases. The regulator can use these tools to identify the economic value of reducing the uncertainty surrounding the cost-effectiveness profile of the several alternatives. This value can be compared with the one that is generated by the actual market share of the different treatment options: one that is the most cost effective and others in the same therapeutic category that, despite producing clinical benefits, are less cost effective. © 2010 Adis Data Information BV.

Type:Article
Title:Un modello di analisi del valore dell'informazione per la valutazione di costo-efficacia nell'ambito del processo regolatorio
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Statistical Science

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